The Analysis of the Medical Research Articles Essay Assignment Paper
The Analysis of the Medical Research Articles Essay Assignment Paper
Research is important in progression. In the medical field research allows for many discoveries, like unearthing the mechanism of DNA replication and designing potential treatments for illnesses. Dr. Paola Marignani is a Professor at Dalhousie University in the Department of Pathology and Department of Biochemistry & Molecular Biology. Dr. Marignani’s research is centered towards discovering the role tumour suppressor proteins play in cellular equilibrium. Out of her 29 publications, I chose three papers that were interesting, contributed to the overall objective and revealed underlying connections to the fundamentals taught in Biochemistry 3400.T
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The first article was about the discovery of a new transcriptional co-activator. During a screening of cDNA for molecules that bind 14-3-3, Kanai et al. (2000) discovered the molecule TAZ. TAZ stands for transcriptional co-activator with PDZ-binding motif. Through analyzing TAZ they were able to identify its binding mechanism to 14-3-3. It was discovered that the PDZ motif on TAZ binds to the protein NHERF-2, and overall can be a part of nuclear transcription at the plasma membrane and cytoskeleton. From there, Kanai et al. determined that 14-3-3 could be a potential regulatory tool for TAZ at the sites.
The article “TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins” (Kanai et al., 2000) introduces a new molecule into the scientific world. Co-activators and regulatory proteins are concepts that I am familiar with from Biochemistry 3400. We learn that co-activators bind to activators to increase the rate of transcription and that regulatory proteins help control the synthesis of proteins. I think it’s really cool that through a simple screening procedure Kanai et al. were able to discover a molecule that may be heavily involved in the transcription of genes at sites other than the plasma membrane and cytoskeleton whilst finding a potential regulatory protein for these reactions. As it pertains to Dr. Marignani’s research, TAZ may not be a tumour suppressor protein but its discovery produced a molecule that plays a role in the human body. Through more tests and analysis of TAZ, there may be a link between TAZ, tumor suppressor proteins and cellular equilibrium. TAZ also has a connection to events regarding nuclear transcription at the cytoskeleton. Cytoskeletal reorganization is something that Dr. Marignani researches, so TAZ may become a molecule worth more research.
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