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Ethical conduct of epidemiologic research with human subjects essay assignment
DQ1 Describe a historical event that has shaped current guidelines and regulations for the ethical conduct of epidemiologic research with human subjects.
DQ2 Describe the key principles, guidelines, and regulations governing research with human subjects and relate them to the Tuskegee experiment and the Guatemalan syphilis study.
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he National Research Act of 19741 created the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research.2 The act charged the commission with identifying the “basic ethical principles which should underlie the conduct of biomedical and behavioral research involving human subjects” and with developing associated guidelines for the ethical conduct of research.3 The resulting Belmont Report, issued in 1978, drew a sharp distinction between research, defined as “an activity designed to test an hypothesis, permit conclusions to be drawn, and thereby to develop or contribute to generalizable knowledge,” and practice, or “interventions…designed solely to enhance the wellbeing of an individual patient or client.”4 In addition, and most important, the report articulated three basic principles that provide the ethical foundation for the conduct of research involving human subjects.
