Critique of the Dopamine Hypothesis of Schizophrenia Essay Assignment Paper
Critique of the Dopamine Hypothesis of Schizophrenia Essay Assignment Paper
Recent scientific discoveries have proofed that the etiology of schizophrenia has various links to the dopaminergic over activity. For instance drugs such as amphetamines have been known to increase the levels of dopamine; in addition, they also increase the psychotic symptoms of schizophrenia. (Abi-Dargham, 2004). Despite the ignorance in its underlying neuronal correlations, the key feature to psychosis distortion are mainly characterized by delusions and hallucinations, However, a study on schizophrenic patients has enriched “the reality of auditory verbal hallucinations(AVH) during functional magnetic resonance imaging (fMRI)” (Nature, June 24, 1976). Binding studies on the dopamine receptors through the positron emission tomography(PET scans) and Postmortem studies have led to conclusions that a disturbance of centralD1 dopamine receptor does exist in schizophrenia. Karlsson et al., (May 2002) on their study, using PET scans, to compare how D1 receptor function between, schizophreniapatients and healthy subjects, concluded that; “binding to D1 receptors did not differ significantlybetween subjects with schizophrenia and healthy subjects inany of the brain regions or for any of the binding measuresstudied.” Their results therefore concluded that there was no major replication to previous postmortem and PET findings which had involved altered central dopamineD1 receptor binding in schizophrenia. Moreover, their findings motivatefurther D1 ligand studies with higher signals in the corticalregions.
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