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Causes of angiopathy
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According to (Lewis, Bucher, Heitkemper, & Harding, 2017), angiopathy is the leading cause of end organ disease secondary to chronic hyperglycemia. There are several theories as to why these complications exist that include toxic byproducts of high glucose metabolism such as sorbitol, the collection of glucose molecules in the basement membranes of capillaries, and a derangement of red blood cell function (Lewis, Bucher, Heitkemper, & Harding, 2017). The microvascular complications are related to the thickening of the capillary membranes that result in micro occlusions. The micro occlusions lead to small herniations with swelling that lead to ischemia and tissue damage most commonly to tissues like the retina and the glomeruli of the kidneys (Lewis, Bucher, Heitkemper, & Harding, 2017).
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