Briefly describe why ivermectin may be severely toxic in some dogs Essay Assignment Paper

Briefly describe why ivermectin may be severely toxic in some dogs. Include in
your answer any potential interactions of ivermectin with other medications

1. Answer all parts of this question:
a) Name two Demodex species recognised in each of the following animals:
(total 3 marks)
i. dog
ii. cat
iii. horse
iv. sheep
v. cow
vi. human.
b) Describe the mechanism of action of isoxazolines and ivermectin that result in
their administration being toxic to demodex mites whilst being comparatively
safe in mammals. (4 marks)

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c) Briefly describe why ivermectin may be severely toxic in some dogs. Include in
your answer any potential interactions of ivermectin with other medications.
(8 marks)
2. Answer all parts of this question:
a) Outline the aetiopathogenesis of leishmaniasis in the dog. (7 marks)
b) List eight (8) recognised cutaneous clinical presentations of leishmaniasis.
(4 marks)
c) List four (4) recognised non cutaneous clinical signs of leishmaniasis.
(2 marks)
d) In a suspected case of leishmaniasis name two (2) samples that you would obtain
from the dog and the test that you would request on each of those samples to
help confirm this diagnosis. (2 marks)
Section B continued over page
Veterinary Dermatology Paper 2 Page 7 of 9
3. Write brief notes on signalment, clinical presentation, pathogenesis and diagnostic
criteria for the following two (2) diseases:
i. mucous membrane pemphigoid (7.5 marks)
ii. mucocutaneous lupus erythematosus. (7.5 marks)
4. Describe the mechanism of action of each of the following:
i. cyclosporine (5 marks)
ii. prednisolone (5 marks)
iii. oclacitinib. (5 marks)