Drug Interactions Assignment Research Essay Paper

The domperidone interacts with a number of drugs and produces adverse reactions. For instance, the ketoconazole and itraconazole are two anti-fungal drugs used to cure infection; any one of these drugs when used in combination with domperidone, it raises the concentration of domperidone in plasma. This adverse reaction is of great concern since both of the medications are used to exclusively treat gastroparesis. Furthermore, the administration of domperidone is also restricted with grapefruit juice. The domperidone’s fundamental metabolic pathway is through CYP3A4. Both the in vitro as well as in vivo data has shown that simultaneous administration of both drugs adversely restricts the enzyme activity resulting in increased levels of domperidone in plasma. However, the concurrent administration of potent CYP3A4 inhibitors and domperidone has evidently shown the unusual prolongation in QT interval and is therefore contraindicated.

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Potent CYP3A4 Inhibitors

Moreover, during the concurrent administration of potent CYP3A4 inhibitors with domperidone, if the patients have shown no prolongation in QT interval, the patient should be closely monitored for possible symptoms and signs of adverse reactions. The examples of such drugs include “anti-arrhythmics class IA” (such as quinidine and disopyramide), “antiarrhythmics class III” (such as sotalol, ibutilide, dronedarone, dofetilide, amiodarone, etc.), certain calcium antagonists (like verapamil, diltiazem), azole antifungals (e.g., voriconazole, ketoconazole, itraconazole, etc.), certain antimalarial agents (such as halofantrine), certain antifungal agents (such as pentamidine), gastrointestinal drugs (such as dolasetron), certain antibiotics (like moxifloxacin, levofloxacin, etc.), certain antidepressants (such as escitalopram, citalopram), certain antipsychotics (such as sertindole, pimozide, haloperidol, etc.), HIV protease inhibitors (like ritonavir, nelfinavir, saquinavir, indinavir, fosamprenavir, atazanavir, amprenavir), certain anti-cancer medications (like vandetanib, toremifene, etc.), macrolide antibiotics (such as erythromycin, clarithromycin, etc.), as well as other drugs such as telithromycin, nefazodone, methadone, bepridil, aprepitant, etc.Drug Interactions Assignment Research

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